Ultrasound Applications in the Treatment of Major Depressive Disorder (MDD): A Systematic Review of Techniques and Efficacy
Published in medRxiv, 2025
This paper is currently under review. Our findings show Low Intensity Focused Ultrasound neuromodulation showed a medium to large effect in reducing depressive behaviors in both rodent models and human trials, representing a promising, noninvasive option for treating refractory MDD.
Recommended citation: Tan, G., Chen, H., & Leuthardt, E. C. (2025). Ultrasound Applications in the Treatment of Major Depressive Disorder (MDD): A Systematic Review of Techniques and Efficacy. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2025.01.23.25320960
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